5I8H

Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting Antibody PGT122 Fab and Fusion Peptide-targeting Antibody VRC34.01 Fab

Summary for 5I8H

• Entry DOI: 10.2210/pdb5i8h/pdb
• Related: 5I8C 5I8E
• Descriptor: BG505 SOSIP.664 gp120, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: hiv-1, envelope, trimer, fusion peptide, antibody, neutralizing, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 354774.26

Authors

Xu, K.,Zhou, T.,Kwong, P.D. (deposition date: 2016-02-18, release date: 2016-05-25, Last modification date: 2020-07-29)

• Primary citation: Kong, R.,Xu, K.,Zhou, T.,Acharya, P.,Lemmin, T.,Liu, K.,Ozorowski, G.,Soto, C.,Taft, J.D.,Bailer, R.T.,Cale, E.M.,Chen, L.,Choi, C.W.,Chuang, G.Y.,Doria-Rose, N.A.,Druz, A.,Georgiev, I.S.,Gorman, J.,Huang, J.,Joyce, M.G.,Louder, M.K.,Ma, X.,McKee, K.,O'Dell, S.,Pancera, M.,Yang, Y.,Blanchard, S.C.,Mothes, W.,Burton, D.R.,Koff, W.C.,Connors, M.,Ward, A.B.,Kwong, P.D.,Mascola, J.R.; Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.; Science, 352:828-833, 2016; PubMed: 27174988; DOI: 10.1126/science.aae0474

Experimental method

X-RAY DIFFRACTION (4.301 Å)