5I5Y
X-RAY CRYSTAL STRUCTURE AT 1.81A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH AN ARYL ACETATE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR.
Summary for 5I5Y
Entry DOI | 10.2210/pdb5i5y/pdb |
Related | 5I5S 5I5T 5I5U 5I5V 5I5W 5I5X 5I60 |
Descriptor | Branched-chain-amino-acid aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, {2-[(5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carbonyl)amino]phenyl}acetic acid, ... (7 entities in total) |
Functional Keywords | fold type iv, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform A: Mitochondrion. Isoform B: Cytoplasm: O15382 |
Total number of polymer chains | 2 |
Total formula weight | 85424.30 |
Authors | Somers, D.O. (deposition date: 2016-02-15, release date: 2016-03-23, Last modification date: 2024-05-01) |
Primary citation | Borthwick, J.A.,Ancellin, N.,Bertrand, S.M.,Bingham, R.P.,Carter, P.S.,Chung, C.W.,Churcher, I.,Dodic, N.,Fournier, C.,Francis, P.L.,Hobbs, A.,Jamieson, C.,Pickett, S.D.,Smith, S.E.,Somers, D.O.,Spitzfaden, C.,Suckling, C.J.,Young, R.J. Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. J.Med.Chem., 59:2452-2467, 2016 Cited by PubMed: 26938474DOI: 10.1021/acs.jmedchem.5b01607 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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