5HCL
Crystal Structure of the first bromodomain of BRD4 in complex with DMA
Summary for 5HCL
Entry DOI | 10.2210/pdb5hcl/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N},~{N}-dimethylethanamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15248.57 |
Authors | Dong, J.,Weber, F.E.,Caflisch, A. (deposition date: 2016-01-04, release date: 2017-01-25, Last modification date: 2024-01-10) |
Primary citation | Ghayor, C.,Gjoksi, B.,Dong, J.,Siegenthaler, B.,Caflisch, A.,Weber, F.E. N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment. Sci Rep, 7:42108-42108, 2017 Cited by PubMed: 28176838DOI: 10.1038/srep42108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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