5H08
Human PTPRZ D1 domain complexed with NAZ2329
Summary for 5H08
Entry DOI | 10.2210/pdb5h08/pdb |
Related | 5AWX |
Descriptor | Receptor-type tyrosine-protein phosphatase zeta, 3-{[2-Ethoxy-5-(trifluoromethyl)benzyl]sulfanyl}-N-(phenylsulfonyl)thiophene-2-carboxamide (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted : P23471 |
Total number of polymer chains | 1 |
Total formula weight | 34455.96 |
Authors | Sugawara, H. (deposition date: 2016-10-04, release date: 2017-07-26, Last modification date: 2023-11-08) |
Primary citation | Fujikawa, A.,Sugawara, H.,Tanaka, T.,Matsumoto, M.,Kuboyama, K.,Suzuki, R.,Tanga, N.,Ogata, A.,Masumura, M.,Noda, M. Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells Sci Rep, 7:5609-5609, 2017 Cited by PubMed: 28717188DOI: 10.1038/s41598-017-05931-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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