5G15

Structure Aurora A (122-403) bound to activating monobody Mb1 and AMPPCP

Summary for 5G15

Entry DOI	10.2210/pdb5g15/pdb
Related	5G16
Descriptor	AURORA A KINASE, MB1 MONOBODY, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (6 entities in total)
Functional Keywords	transferase, aurora a, monobody, amppcp, kinase, activation, allostery, cell cycle, cancer
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	44180.82
Authors	Zorba, A.,Kutter, S.,Kern, D.,Koide, S.,Koide, A. (deposition date: 2016-03-23, release date: 2018-03-14, Last modification date: 2024-01-10)
Primary citation	Zorba, A.,Nguyen, V.,Koide, A.,Hoemberger, M.,Zheng, Y.,Kutter, S.,Kim, C.,Koide, S.,Kern, D. Allosteric modulation of a human protein kinase with monobodies. Proc.Natl.Acad.Sci.USA, 116:13937-13942, 2019 Cited by PubMed: 31239342 DOI: 10.1073/pnas.1906024116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation