5G0O
Structure of rat neuronal nitric oxide synthase D597N mutant heme domain in complex with 4-METHYL-6-(2-(5-(4-METHYLPIPERAZIN-1-YL) PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE
Summary for 5G0O
Entry DOI | 10.2210/pdb5g0o/pdb |
Related | 5G0N 5G0P |
Descriptor | NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | oxidoreductase, nitric oxide synthase, inhibitor complex |
Biological source | RATTUS NORVEGICUS (NORWAY RAT) |
Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100144.90 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2016-03-21, release date: 2016-06-15, Last modification date: 2024-05-08) |
Primary citation | Li, H.,Wang, H.,Kang, S.,Silverman, R.B.,Poulos, T.L. Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase. Biochemistry, 55:3702-, 2016 Cited by PubMed: 27250740DOI: 10.1021/ACS.BIOCHEM.6B00261 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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