5FDQ

Murine COX-2 S530T mutant

Summary for 5FDQ

• Entry DOI: 10.2210/pdb5fdq/pdb
• Related: 5F19 5F1A
• Descriptor: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: cyclooxygenase, cyxlooxygenase-2, monotopic, cox-2, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 139969.79

Authors

Lucido, M.J.,Orlando, B.J.,Malkowski, M.G. (deposition date: 2015-12-16, release date: 2016-03-16, Last modification date: 2023-09-27)

• Primary citation: Lucido, M.J.,Orlando, B.J.,Vecchio, A.J.,Malkowski, M.G.; Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.; Biochemistry, 55:1226-1238, 2016; PubMed: 26859324; DOI: 10.1021/acs.biochem.5b01378

Experimental method

X-RAY DIFFRACTION (1.9 Å)