5FBI
COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND 3b
Summary for 5FBI
Entry DOI | 10.2210/pdb5fbi/pdb |
Descriptor | Complement factor D, GLYCEROL, 3-[(2-aminocarbonyl-1~{H}-indol-5-yl)oxymethyl]benzoic acid, ... (4 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P00746 |
Total number of polymer chains | 1 |
Total formula weight | 25141.52 |
Authors | Ostermann, N.,Zink, F. (deposition date: 2015-12-14, release date: 2016-10-26, Last modification date: 2024-10-09) |
Primary citation | Maibaum, J.,Liao, S.M.,Vulpetti, A.,Ostermann, N.,Randl, S.,Rudisser, S.,Lorthiois, E.,Erbel, P.,Kinzel, B.,Kolb, F.A.,Barbieri, S.,Wagner, J.,Durand, C.,Fettis, K.,Dussauge, S.,Hughes, N.,Delgado, O.,Hommel, U.,Gould, T.,Mac Sweeney, A.,Gerhartz, B.,Cumin, F.,Flohr, S.,Schubart, A.,Jaffee, B.,Harrison, R.,Risitano, A.M.,Eder, J.,Anderson, K. Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat.Chem.Biol., 12:1105-1110, 2016 Cited by PubMed: 27775713DOI: 10.1038/nchembio.2208 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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