5F2P
Crystal structure of the BRD9 bromodomain in complex with compound 3.
Summary for 5F2P
Entry DOI | 10.2210/pdb5f2p/pdb |
Descriptor | BRD9, 2-(dimethylamino)-6-methyl-pyrido[4,3-d]pyrimidin-5-one (3 entities in total) |
Functional Keywords | bromodomain, inhibitor, regulatory proteins, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 28907.98 |
Authors | Nar, H.,Fiegen, D.,Zoephel, A.,Bader, G. (deposition date: 2015-12-02, release date: 2016-03-09, Last modification date: 2024-01-10) |
Primary citation | Martin, L.J.,Koegl, M.,Bader, G.,Cockcroft, X.L.,Fedorov, O.,Fiegen, D.,Gerstberger, T.,Hofmann, M.H.,Hohmann, A.F.,Kessler, D.,Knapp, S.,Knesl, P.,Kornigg, S.,Muller, S.,Nar, H.,Rogers, C.,Rumpel, K.,Schaaf, O.,Steurer, S.,Tallant, C.,Vakoc, C.R.,Zeeb, M.,Zoephel, A.,Pearson, M.,Boehmelt, G.,McConnell, D. Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J.Med.Chem., 59:4462-4475, 2016 Cited by PubMed: 26914985DOI: 10.1021/acs.jmedchem.5b01865 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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