5EDT
Crystal structure of Mycobacterium tuberculosis CYP121 in complex with LIG9
Summary for 5EDT
Entry DOI | 10.2210/pdb5edt/pdb |
Related | 4KTF |
Descriptor | Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, 2-azanyl-5-chloranyl-benzamide, ... (5 entities in total) |
Functional Keywords | cytochrome p450, cyp121, mycobacterium tuberculosis, fragment-based drug discovery, oxidoreductase |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 1 |
Total formula weight | 44922.38 |
Authors | Kavanagh, M.E.,Coyne, A.G.,McLean, K.J.,James, G.G.,Levy, C.,Marino, L.B.,Carvalho, L.P.D.,Chan, D.S.H.,Hudson, S.A.,Surade, S.,Munro, A.W.,Abell, C. (deposition date: 2015-10-22, release date: 2016-04-06, Last modification date: 2024-01-10) |
Primary citation | Kavanagh, M.E.,Coyne, A.G.,McLean, K.J.,James, G.G.,Levy, C.W.,Marino, L.B.,de Carvalho, L.P.,Chan, D.S.,Hudson, S.A.,Surade, S.,Leys, D.,Munro, A.W.,Abell, C. Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59:3272-3302, 2016 Cited by PubMed: 27002486DOI: 10.1021/acs.jmedchem.6b00007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
Download full validation report