5EA9
Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0130
Summary for 5EA9
Entry DOI | 10.2210/pdb5ea9/pdb |
Related | 5E93 |
Descriptor | Dihydroorotate dehydrogenase (fumarate), 5-[(E)-3-thiophen-2-ylprop-2-enylidene]-1,3-diazinane-2,4,6-trione, GLYCEROL, ... (7 entities in total) |
Functional Keywords | t. cruzi, dihydroorotate dehydrogenase, covalent inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Trypanosoma cruzi strain CL Brener |
Total number of polymer chains | 2 |
Total formula weight | 71920.04 |
Authors | Rocha, J.R.,Inaoka, D.K.,Cheleski, J.,Shiba, T.,Harada, S.,Montanari, C.A.,Kita, K. (deposition date: 2015-10-15, release date: 2016-10-19, Last modification date: 2020-02-19) |
Primary citation | Rocha, J.R.,Cheleski, J.,Inaoka, D.K.,Avelar, L.A.,Ribeiro, J.F.R.,Wiggers, H.J.,Albuquerque, S.,Shiba, T.,Harada, S.,Kita, K.,Silva, A.B.F.,Montanari, C.A. Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity To be Published, |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
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