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5E8A

Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor

Summary for 5E8A
Entry DOI10.2210/pdb5e8a/pdb
Related5E88 5E89
DescriptorGalectin-3, CHLORIDE ION, 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, ... (4 entities in total)
Functional Keywordscarbohydrate-recognition, beta sandwich, carbohydrate binding protein, sugar binding protein, inhibitor, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P17931
Total number of polymer chains1
Total formula weight16442.19
Authors
Collins, P.M.,Blanchard, H. (deposition date: 2015-10-13, release date: 2016-08-24, Last modification date: 2023-09-27)
Primary citationDelaine, T.,Collins, P.,MacKinnon, A.,Sharma, G.,Stegmayr, J.,Rajput, V.K.,Mandal, S.,Cumpstey, I.,Larumbe, A.,Salameh, B.A.,Kahl-Knutsson, B.,van Hattum, H.,van Scherpenzeel, M.,Pieters, R.J.,Sethi, T.,Schambye, H.,Oredsson, S.,Leffler, H.,Blanchard, H.,Nilsson, U.J.
Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.
Chembiochem, 17:1759-1770, 2016
Cited by
PubMed: 27356186
DOI: 10.1002/cbic.201600285
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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