5E29

Crystal Structure of Deoxygenated Hemoglobin in Complex with an Allosteric Effector and Nitric Oxide

Summary for 5E29

• Entry DOI: 10.2210/pdb5e29/pdb
• Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRIC OXIDE, ... (9 entities in total)
• Functional Keywords: hemoglobin, right-shifter, nitric oxide, oxygen transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 65783.05

Authors

Safo, M.K.,Deshpande, T.M. (deposition date: 2015-09-30, release date: 2015-10-14, Last modification date: 2023-09-27)

• Primary citation: Xu, G.G.,Deshpande, T.M.,Ghatge, M.S.,Mehta, A.Y.,Omar, A.S.,Ahmed, M.H.,Venitz, J.,Abdulmalik, O.,Zhang, Y.,Safo, M.K.; Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry.; Biochemistry, 54:7178-7192, 2015; PubMed: 26582149; DOI: 10.1021/acs.biochem.5b01074

Experimental method

X-RAY DIFFRACTION (1.85 Å)