5DUQ

Active human c1-inhibitor in complex with dextran sulfate

Summary for 5DUQ

• Entry DOI: 10.2210/pdb5duq/pdb
• Related: 5DU3
• Related PRD ID: PRD_900023
• Descriptor: Plasma protease C1 inhibitor, beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: serine protein inhibitor, complex with glycosaminoglycan, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P05155
• Total number of polymer chains: 2
• Total formula weight: 86871.75

Authors

Dijk, M.,Holkers, J.,Voskamp, P.,Giannetti, B.M.,Waterreus, W.J.,van Veen, H.A.,Pannu, N.S. (deposition date: 2015-09-20, release date: 2016-08-31, Last modification date: 2020-07-29)

• Primary citation: Dijk, M.,Holkers, J.,Voskamp, P.,Giannetti, B.M.,Waterreus, W.J.,van Veen, H.A.,Pannu, N.S.; How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation.; Structure, 24:2182-2189, 2016; PubMed: 27818099; DOI: 10.1016/j.str.2016.09.013

Experimental method

X-RAY DIFFRACTION (2.9 Å)