5DP0
Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a 4-fluorophenylamino-substituted triaryl-ethylene derivative 4,4'-(2-{3-[(4-fluorophenyl)amino]phenyl}ethene-1,1-diyl)diphenol
Summary for 5DP0
Entry DOI | 10.2210/pdb5dp0/pdb |
Related | 5DLR |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, 4,4'-(2-{3-[(4-fluorophenyl)amino]phenyl}ethene-1,1-diyl)diphenol, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 |
Total number of polymer chains | 4 |
Total formula weight | 62727.84 |
Authors | Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Cavett, V.,Nowak, J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. (deposition date: 2015-09-11, release date: 2016-05-04, Last modification date: 2023-09-27) |
Primary citation | Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Nowak, J.,Wright, N.J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12:864-864, 2016 Cited by PubMed: 27107013DOI: 10.15252/msb.20156701 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.382 Å) |
Structure validation
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