5DH3
Crystal structure of MST2 in complex with XMU-MP-1
Summary for 5DH3
Entry DOI | 10.2210/pdb5dh3/pdb |
Descriptor | Serine/threonine-protein kinase 3, 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | mst2, mst1, hippo pathway, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q13188 |
Total number of polymer chains | 2 |
Total formula weight | 72443.98 |
Authors | Kong, L.L.,Yun, C.H. (deposition date: 2015-08-29, release date: 2016-08-31, Last modification date: 2023-11-08) |
Primary citation | Fan, F.,He, Z.,Kong, L.L.,Chen, Q.,Yuan, Q.,Zhang, S.,Ye, J.,Liu, H.,Sun, X.,Geng, J.,Yuan, L.,Hong, L.,Xiao, C.,Zhang, W.,Sun, X.,Li, Y.,Wang, P.,Huang, L.,Wu, X.,Ji, Z.,Wu, Q.,Xia, N.S.,Gray, N.S.,Chen, L.,Yun, C.H.,Deng, X.,Zhou, D. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration Sci Transl Med, 8:352ra108-352ra108, 2016 Cited by PubMed: 27535619DOI: 10.1126/scitranslmed.aaf2304 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.468 Å) |
Structure validation
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