5KCW
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with an N-trifluoroethyl OBHS-N derivative
Replaces: 5BPRSummary for 5KCW
Entry DOI | 10.2210/pdb5kcw/pdb |
Related | 5KCC 5KCD 5KCF 5KCT 5KCU 5KD9 |
Descriptor | Estrogen receptor, NCOA2, (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-N-phenyl-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 63485.51 |
Authors | Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Dharmarajan, V.,Goswami, D.,Kastrati, I.,Novick, S.,Nowak, J.,Zhou, H.B.,Boonmuen, N.,Zhao, Y.,Min, J.,Frasor, J.,Katzenellenbogen, B.S.,Griffin, P.R.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2016-06-07, release date: 2016-11-16, Last modification date: 2024-03-06) |
Primary citation | Srinivasan, S.,Nwachukwu, J.C.,Bruno, N.E.,Dharmarajan, V.,Goswami, D.,Kastrati, I.,Novick, S.,Nowak, J.,Cavett, V.,Zhou, H.B.,Boonmuen, N.,Zhao, Y.,Min, J.,Frasor, J.,Katzenellenbogen, B.S.,Griffin, P.R.,Katzenellenbogen, J.A.,Nettles, K.W. Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nat. Chem. Biol., 13:111-118, 2017 Cited by PubMed: 27870835DOI: 10.1038/nchembio.2236 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.905 Å) |
Structure validation
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