5AYG
Crystal Structure of the Human ROR gamma Ligand Binding Domain With 3g
Summary for 5AYG
Entry DOI | 10.2210/pdb5ayg/pdb |
Descriptor | Nuclear receptor ROR-gamma, 3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-yl-propanamide (3 entities in total) |
Functional Keywords | inhibitor, complex, nuclear receptor, dna binding protein-inhibitor complex, dna binding protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 60606.13 |
Authors | Noguchi, M.,Doi, S.,Nomura, A.,Kikuwaka, M.,Murase, K.,Hirata, K.,Kamada, M.,Adachi, T. (deposition date: 2015-08-20, release date: 2016-03-02, Last modification date: 2023-11-08) |
Primary citation | Hirata, K.,Kotoku, M.,Seki, N.,Maeba, T.,Maeda, K.,Hirashima, S.,Sakai, T.,Obika, S.,Hori, A.,Hase, Y.,Yamaguchi, T.,Katsuda, Y.,Hata, T.,Miyagawa, N.,Arita, K.,Nomura, Y.,Asahina, K.,Aratsu, Y.,Kamada, M.,Adachi, T.,Noguchi, M.,Doi, S.,Crowe, P.,Bradley, E.,Steensma, R.,Tao, H.,Fenn, M.,Babine, R.,Li, X.,Thacher, S.,Hashimoto, H.,Shiozaki, M. SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor Acs Med.Chem.Lett., 7:23-27, 2016 Cited by PubMed: 26819660DOI: 10.1021/acsmedchemlett.5b00253 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report