5A5P
Crystal structure of human ATAD2 bromodomain in complex with 8-2-(dimethylamino)ethylamino-3-methyl-1,2-dihydroquinolin-2-one
Summary for 5A5P
Entry DOI | 10.2210/pdb5a5p/pdb |
Related | 5A5N 5A5O 5A5Q 5A5R 5A5S |
Descriptor | ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, 8-{[2-(dimethylamino)ethyl]amino}-3-methyl-1,2-dihydroquinolin-2-one, ... (5 entities in total) |
Functional Keywords | hydrolase, inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2 |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : Q6PL18 |
Total number of polymer chains | 1 |
Total formula weight | 15919.03 |
Authors | Chung, C.,Bamborough, P.,Demont, E. (deposition date: 2015-06-20, release date: 2015-07-22, Last modification date: 2024-05-08) |
Primary citation | Demont, E.H.,Chung, C.,Furze, R.C.,Grandi, P.,Michon, A.,Wellaway, C.,Barrett, N.,Bridges, A.M.,Craggs, P.D.,Diallo, H.,Dixon, D.P.,Douault, C.,Emmons, A.J.,Jones, E.J.,Karamshi, B.V.,Locke, K.,Mitchell, D.J.,Mouzon, B.H.,Prinjha, R.K.,Roberts, A.D.,Sheppard, R.J.,Watson, R.J.,Bamborough, P. Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors. J.Med.Chem., 58:5649-, 2015 Cited by PubMed: 26155854DOI: 10.1021/ACS.JMEDCHEM.5B00772 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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