4ZXT

Complex of ERK2 with catechol

Summary for 4ZXT

• Entry DOI: 10.2210/pdb4zxt/pdb
• Related: 4N0S
• Descriptor: Mitogen-activated protein kinase 1, CATECHOL, SULFATE ION, ... (5 entities in total)
• Functional Keywords: catechol complex, mitogen-activated protein kinase, signal-regulated kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton, spindle : P28482
• Total number of polymer chains: 1
• Total formula weight: 42107.39

Authors

Kurinov, I.,Malakhova, M. (deposition date: 2015-05-20, release date: 2016-05-25, Last modification date: 2016-10-05)

• Primary citation: Lim do, Y.,Shin, S.H.,Lee, M.H.,Malakhova, M.,Kurinov, I.,Wu, Q.,Xu, J.,Jiang, Y.,Dong, Z.,Liu, K.,Lee, K.Y.,Bae, K.B.,Choi, B.Y.,Deng, Y.,Bode, A.,Dong, Z.; A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer.; Oncotarget, 7:35001-35014, 2016; PubMed: 27167001; DOI: 10.18632/oncotarget.9223

Experimental method

X-RAY DIFFRACTION (2 Å)