4ZWE
Crystal structure of the dGTP-bound catalytic core of SAMHD1 T592V mutant
Summary for 4ZWE
Entry DOI | 10.2210/pdb4zwe/pdb |
Related | 4zwg |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | phosphorylation, tetramer stability, dntpase, hiv-1 restriction, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 244616.51 |
Authors | |
Primary citation | Tang, C.,Ji, X.,Wu, L.,Xiong, Y. Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592. J.Biol.Chem., 290:26352-26359, 2015 Cited by PubMed: 26294762DOI: 10.1074/jbc.M115.677435 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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