4ZTS

Human Aurora A catalytic domain bound to FK1142

4ZTS の概要

• エントリーDOI: 10.2210/pdb4zts/pdb
• 分子名称: Aurora kinase A, (2Z,5Z)-2-[(4-ethylphenyl)imino]-3-methyl-5-[(2-{[4-(1H-tetrazol-5-yl)phenyl]amino}pyridin-4-yl)methylidene]-1,3-thiazolidin-4-one, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
• 機能のキーワード: aurora, kinase, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33549.51

構造登録者

Marcaida, M.J.,Kilchmann, F.,Schick, T.,Reymond, J.L. (登録日: 2015-05-15, 公開日: 2016-07-20, 最終更新日: 2024-01-10)

• 主引用文献: Kilchmann, F.,Marcaida, M.J.,Kotak, S.,Schick, T.,Boss, S.D.,Awale, M.,Gonczy, P.,Reymond, J.L.; Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.; J.Med.Chem., 59:7188-7211, 2016; PubMed: 27391133; DOI: 10.1021/acs.jmedchem.6b00709

実験手法

X-RAY DIFFRACTION (2.9 Å)