4ZTM
Irak4-inhibitor co-structure
Summary for 4ZTM
Entry DOI | 10.2210/pdb4ztm/pdb |
Related | 4ZTL 4ZTN |
Descriptor | Interleukin-1 receptor-associated kinase 4, 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3H)-one (3 entities in total) |
Functional Keywords | kinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9NWZ3 |
Total number of polymer chains | 4 |
Total formula weight | 137542.75 |
Authors | Fischmann, T.O. (deposition date: 2015-05-14, release date: 2015-09-02, Last modification date: 2023-09-27) |
Primary citation | Seganish, W.M.,Fischmann, T.O.,Sherborne, B.,Matasi, J.,Lavey, B.,McElroy, W.T.,Tulshian, D.,Tata, J.,Sondey, C.,Garlisi, C.G.,Devito, K.,Fossetta, J.,Lundell, D.,Niu, X. Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors. Acs Med.Chem.Lett., 6:942-947, 2015 Cited by PubMed: 26288698DOI: 10.1021/acsmedchemlett.5b00279 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.66 Å) |
Structure validation
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