4ZTJ

Crystal Structure of the Prototype Foamy Virus Intasome with a 2-Pyridinone Aminal Inhibitor

Summary for 4ZTJ

• Entry DOI: 10.2210/pdb4ztj/pdb
• Related: 4ZTF
• Descriptor: PFV INTEGRASE, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (9 entities in total)
• Functional Keywords: transferase-dna complex, dna integration, viral protein, recombination-inhibitor-dna complex, transferase-dna-inhibitor complex, transferase/dna/inhibitor
• Biological source: Human spumaretrovirus (SFVcpz(hu)); More
• Cellular location: Integrase: Virion . Protease/Reverse transcriptase/ribonuclease H: Host nucleus : P14350
• Total number of polymer chains: 4
• Total formula weight: 101226.38

Authors

Klein, D.J.,Patel, S. (deposition date: 2015-05-14, release date: 2015-10-07, Last modification date: 2024-03-06)

• Primary citation: Raheem, I.T.,Walji, A.M.,Klein, D.,Sanders, J.M.,Powell, D.A.,Abeywickrema, P.,Barbe, G.,Bennet, A.,Clas, S.D.,Dubost, D.,Embrey, M.,Grobler, J.,Hafey, M.J.,Hartingh, T.J.,Hazuda, D.J.,Miller, M.D.,Moore, K.P.,Pajkovic, N.,Patel, S.,Rada, V.,Rearden, P.,Schreier, J.D.,Sisko, J.,Steele, T.G.,Truchon, J.F.,Wai, J.,Xu, M.,Coleman, P.J.; Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.; J.Med.Chem., 58:8154-8165, 2015; PubMed: 26397965; DOI: 10.1021/acs.jmedchem.5b01037

Experimental method

X-RAY DIFFRACTION (2.67 Å)