4ZTF
Crystal Structure of the Prototype Foamy Virus Intasome with a 2-Pyridinone Aminal Inhibitor
4ZTF の概要
エントリーDOI | 10.2210/pdb4ztf/pdb |
分子名称 | Integrase, 19 NUCLEOTIDE PREPROCESSED PFV DONOR DNA (NON-TRANSFERRED STRAND), 17 NUCLEOTIDE PREPROCESSED PFV DONOR DNA (TRANSFERRED STRAND), ... (9 entities in total) |
機能のキーワード | transferase-dna complex, dna integration, viral protein, recombination-inhibitor-dna complex, transferase-dna-inhibitor complex, transferase/dna/inhibitor |
由来する生物種 | Human spumaretrovirus (SFVcpz(hu)) 詳細 |
細胞内の位置 | Integrase: Virion . Protease/Reverse transcriptase/ribonuclease H: Host nucleus : P14350 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 101240.41 |
構造登録者 | |
主引用文献 | Raheem, I.T.,Walji, A.M.,Klein, D.,Sanders, J.M.,Powell, D.A.,Abeywickrema, P.,Barbe, G.,Bennet, A.,Clas, S.D.,Dubost, D.,Embrey, M.,Grobler, J.,Hafey, M.J.,Hartingh, T.J.,Hazuda, D.J.,Miller, M.D.,Moore, K.P.,Pajkovic, N.,Patel, S.,Rada, V.,Rearden, P.,Schreier, J.D.,Sisko, J.,Steele, T.G.,Truchon, J.F.,Wai, J.,Xu, M.,Coleman, P.J. Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors. J.Med.Chem., 58:8154-8165, 2015 Cited by PubMed: 26397965DOI: 10.1021/acs.jmedchem.5b01037 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7 Å) |
構造検証レポート
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