4ZSW

Pig Brain GABA-AT inactivated by (E)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic acid

Summary for 4ZSW

• Entry DOI: 10.2210/pdb4zsw/pdb
• Related: 4ZSY
• Descriptor: 4-aminobutyrate aminotransferase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, (1S)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopent-3-ene-1,3-dicarboxylic acid, ... (6 entities in total)
• Functional Keywords: gaba aminotransferase, amino-4-fluoromethylenyl-1-cyclopentanoic acid, inactivation, mechanism-based, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Sus scrofa (Pig)
• Total number of polymer chains: 4
• Total formula weight: 211166.92

Authors

Wu, R.,Lee, H.,Le, H.V.,Doud, E.,Sanishvili, R.,Compton, P.,Kelleher, N.L.,Silverman, R.B.,Liu, D. (deposition date: 2015-05-14, release date: 2015-07-08, Last modification date: 2024-03-06)

• Primary citation: Lee, H.,Le, H.V.,Wu, R.,Doud, E.,Sanishvili, R.,Kellie, J.F.,Compton, P.D.,Pachaiyappan, B.,Liu, D.,Kelleher, N.L.,Silverman, R.B.; Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid.; Acs Chem.Biol., 10:2087-2098, 2015; PubMed: 26110556; DOI: 10.1021/acschembio.5b00212

Experimental method

X-RAY DIFFRACTION (1.7 Å)