4ZSL
MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR
Summary for 4ZSL
Entry DOI | 10.2210/pdb4zsl/pdb |
Related | 4ZSG |
Descriptor | Mitogen-activated protein kinase 7, 3-amino-5-[(4-chlorophenyl)amino]-N-[(1S)-1-phenylethyl]-1H-1,2,4-triazole-1-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q13164 |
Total number of polymer chains | 1 |
Total formula weight | 39954.38 |
Authors | Ogg, D.J.,Tucker, J. (deposition date: 2015-05-13, release date: 2016-05-04, Last modification date: 2024-05-01) |
Primary citation | Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Phillips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D. Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site. Acta Crystallogr D Struct Biol, 72:682-693, 2016 Cited by PubMed: 27139631DOI: 10.1107/S2059798316004502 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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