4ZP3

AKAP18:PKA-RIIalpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA

4ZP3 の概要

• エントリーDOI: 10.2210/pdb4zp3/pdb
• 分子名称: cAMP-dependent protein kinase type II-alpha regulatory subunit, A-kinase anchor protein 7 isoforms alpha and beta, CADMIUM ION, ... (4 entities in total)
• 機能のキーワード: anchor points, amphiphathic helix, akap, dd-domain, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm : P13861; Isoform Alpha: Lateral cell membrane; Lipid- anchor. Isoform Beta: Apical cell membrane; Lipid- anchor: O43687
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 87385.71

構造登録者

Goetz, F.,Roske, Y.,Faelber, K.,Zuehlke, K.,Autenrieth, K.,Kreuchwig, A.,Krause, G.,Herberg, F.W.,Daumke, O.,Heinemann, U.,Klussmann, E. (登録日: 2015-05-07, 公開日: 2016-05-04, 最終更新日: 2024-05-08)

• 主引用文献: Gotz, F.,Roske, Y.,Schulz, M.S.,Autenrieth, K.,Bertinetti, D.,Faelber, K.,Zuhlke, K.,Kreuchwig, A.,Kennedy, E.J.,Krause, G.,Daumke, O.,Herberg, F.W.,Heinemann, U.,Klussmann, E.; AKAP18:PKA-RII alpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA.; Biochem.J., 473:1881-1894, 2016; PubMed: 27102985; DOI: 10.1042/BCJ20160242

実験手法

X-RAY DIFFRACTION (2.63 Å)