4ZOP

Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor

4ZOP の概要

• エントリーDOI: 10.2210/pdb4zop/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (2S,3R)-N~1~-(8-tert-butyl-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide, ... (4 entities in total)
• 機能のキーワード: lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 160458.61

構造登録者

Knapp, M.S.,Elling, R.A. (登録日: 2015-05-06, 公開日: 2016-05-18, 最終更新日: 2023-09-27)

• 主引用文献: Fairhurst, R.A.,Gerspacher, M.,Imbach-Weese, P.,Mah, R.,Caravatti, G.,Fuert, P.,Fritsch, C.,Schnell, C.,Blanz, J.,Blasco, F.,Desrayaud, S.,Guthy, D.A.,Knapp, M.S.,Arz, D.,Wirth, J.,Roehn-Carnemolla, E.,Luu, V.H.; Co-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitorCo-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor; To Be Published,

実験手法

X-RAY DIFFRACTION (2.62 Å)