4ZO5
PDE10 complexed with 4-isopropoxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)isoindoline-1,3-dione
Summary for 4ZO5
Entry DOI | 10.2210/pdb4zo5/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phosphodiesterase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 75873.63 |
Authors | |
Primary citation | Cox, C.D.,Hostetler, E.D.,Flores, B.A.,Evelhoch, J.L.,Fan, H.,Gantert, L.,Holahan, M.,Eng, W.,Joshi, A.,McGaughey, G.,Meng, X.,Purcell, M.,Raheem, I.T.,Riffel, K.,Yan, Y.,Renger, J.J.,Smith, S.M.,Coleman, P.J. Discovery of [(11)C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors. Bioorg.Med.Chem.Lett., 25:4893-4898, 2015 Cited by PubMed: 26077491DOI: 10.1016/j.bmcl.2015.05.080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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