4ZN9

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Oxabicyclic Heptene Sulfonate (OBHS)

4ZN9 の概要

• エントリーDOI: 10.2210/pdb4zn9/pdb
• 関連するPDBエントリー: 4PP6 4ZN7 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW
• 分子名称: Estrogen receptor, Nuclear receptor-interacting peptide, cyclohexa-2,5-dien-1-yl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, ... (4 entities in total)
• 機能のキーワード: protein ligand complex, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Nucleus: Q15596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62695.63

構造登録者

Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Cavett, V.,Nowak, J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. (登録日: 2015-05-04, 公開日: 2015-09-09, 最終更新日: 2024-03-06)

• 主引用文献: Zheng, Y.,Zhu, M.,Srinivasan, S.,Nwachukwu, J.C.,Cavett, V.,Min, J.,Carlson, K.E.,Wang, P.,Dong, C.,Katzenellenbogen, J.A.,Nettles, K.W.,Zhou, H.B.; Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.; Chemmedchem, 7:1094-1100, 2012; PubMed: 22517684; DOI: 10.1002/cmdc.201200048

実験手法

X-RAY DIFFRACTION (2.215 Å)