4ZM4

Complex structure of PctV K276R mutant with PMP and 3-dehydroshkimate

Summary for 4ZM4

• Entry DOI: 10.2210/pdb4zm4/pdb
• Related: 4ZM3
• Descriptor: Aminotransferase, PYRIDOXAL-5'-PHOSPHATE, (3E,4R,5R)-4,5-dihydroxy-3-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}cyclohex-1-ene-1-carboxylic acid, ... (4 entities in total)
• Functional Keywords: pyridoxal 5-phosphate, aminotransferase, transferase
• Biological source: Streptomyces pactum
• Total number of polymer chains: 6
• Total formula weight: 288799.82

Authors

Hirayama, A.,Miyanaga, A.,Kudo, F.,Eguchi, T. (deposition date: 2015-05-02, release date: 2015-10-14, Last modification date: 2023-11-08)

• Primary citation: Hirayama, A.,Miyanaga, A.,Kudo, F.,Eguchi, T.; Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin.; Chembiochem, 16:2484-2490, 2015; PubMed: 26426567; DOI: 10.1002/cbic.201500426

Experimental method

X-RAY DIFFRACTION (2.4 Å)