4ZLS

HIV-1 wild Type protease with GRL-096-13A (a Boc-derivative P2-Ligand, 3,-5-dimethylbiphenyl P1-Ligand)

4ZLS の概要

• エントリーDOI: 10.2210/pdb4zls/pdb
• 関連するPDBエントリー: 2IEN 3OK9 3QAA 4U8W
• 分子名称: Protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: multidrug-resistant strains, hydrolase inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 BH10 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22312.55

構造登録者

Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (登録日: 2015-05-01, 公開日: 2015-07-15, 最終更新日: 2023-09-27)

• 主引用文献: Ghosh, A.K.,Yu, X.,Osswald, H.L.,Agniswamy, J.,Wang, Y.F.,Amano, M.,Weber, I.T.,Mitsuya, H.; Structure-Based Design of Potent HIV-1 Protease Inhibitors with Modified P1-Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme-Inhibitor X-ray Structural Studies.; J.Med.Chem., 58:5334-5343, 2015; PubMed: 26107245; DOI: 10.1021/acs.jmedchem.5b00676

実験手法

X-RAY DIFFRACTION (1.53 Å)