4ZJ9
Small heat shock protein AgsA from Salmonella typhimurium: Alpha crystallin domain
Summary for 4ZJ9
| Entry DOI | 10.2210/pdb4zj9/pdb |
| Related | 4ZJA 4ZJD |
| Descriptor | Aggregation suppressing protein, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total) |
| Functional Keywords | small heat shock protein, crystallin, dimer, chaperone |
| Biological source | Salmonella enterica subsp. enterica serovar Typhimurium |
| Total number of polymer chains | 1 |
| Total formula weight | 17221.27 |
| Authors | Mani, N.,Suguna, K. (deposition date: 2015-04-29, release date: 2016-04-20, Last modification date: 2023-11-08) |
| Primary citation | Mani, N.,Bhandari, S.,Moreno, R.,Hu, L.,Prasad, B.V.,Suguna, K. Multiple oligomeric structures of a bacterial small heat shock protein Sci Rep, 6:24019-24019, 2016 Cited by PubMed Abstract: Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. Owing to the dynamic nature of small heat shock protein oligomers, elucidating the structural basis of chaperone action and oligomerization still remains a challenge. In order to understand the organization of sHSP oligomers, we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in a dimeric form and two higher oligomeric forms: an 18-mer and a 24-mer. Though the core dimer structure is conserved in all the forms, structural heterogeneity arises due to variation in the terminal regions. PubMed: 27053150DOI: 10.1038/srep24019 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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