4ZJ9

Small heat shock protein AgsA from Salmonella typhimurium: Alpha crystallin domain

4ZJ9 の概要

• エントリーDOI: 10.2210/pdb4zj9/pdb
• 関連するPDBエントリー: 4ZJA 4ZJD
• 分子名称: Aggregation suppressing protein, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
• 機能のキーワード: small heat shock protein, crystallin, dimer, chaperone
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17221.27

構造登録者

Mani, N.,Suguna, K. (登録日: 2015-04-29, 公開日: 2016-04-20, 最終更新日: 2023-11-08)

主引用文献

Mani, N.,Bhandari, S.,Moreno, R.,Hu, L.,Prasad, B.V.,Suguna, K.
Multiple oligomeric structures of a bacterial small heat shock protein
Sci Rep, 6:24019-24019, 2016

PubMed Abstract: Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. Owing to the dynamic nature of small heat shock protein oligomers, elucidating the structural basis of chaperone action and oligomerization still remains a challenge. In order to understand the organization of sHSP oligomers, we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in a dimeric form and two higher oligomeric forms: an 18-mer and a 24-mer. Though the core dimer structure is conserved in all the forms, structural heterogeneity arises due to variation in the terminal regions.

PubMed: 27053150
DOI: 10.1038/srep24019

実験手法

X-RAY DIFFRACTION (2 Å)