4ZDK
Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with UTP, AMP-PCP and oxonorleucine
Summary for 4ZDK
Entry DOI | 10.2210/pdb4zdk/pdb |
Descriptor | CTP synthase, 5-OXO-L-NORLEUCINE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | ctp synthase, pyrg, amidotransferase, utp, amp-pcp, 5-oxo-l-norleucine, ligase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 2 |
Total formula weight | 129745.43 |
Authors | Bellinzoni, M.,Barilone, N.,Alzari, P.M. (deposition date: 2015-04-17, release date: 2015-07-01, Last modification date: 2024-01-10) |
Primary citation | Mori, G.,Chiarelli, L.R.,Esposito, M.,Makarov, V.,Bellinzoni, M.,Hartkoorn, R.C.,Degiacomi, G.,Boldrin, F.,Ekins, S.,de Jesus Lopes Ribeiro, A.L.,Marino, L.B.,Centarova, I.,Svetlikova, Z.,Blasko, J.,Kazakova, E.,Lepioshkin, A.,Barilone, N.,Zanoni, G.,Porta, A.,Fondi, M.,Fani, R.,Baulard, A.R.,Mikusova, K.,Alzari, P.M.,Manganelli, R.,de Carvalho, L.P.,Riccardi, G.,Cole, S.T.,Pasca, M.R. Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22:917-927, 2015 Cited by PubMed: 26097035DOI: 10.1016/j.chembiol.2015.05.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.49 Å) |
Structure validation
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