4ZDK

Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with UTP, AMP-PCP and oxonorleucine

4ZDK の概要

• エントリーDOI: 10.2210/pdb4zdk/pdb
• 分子名称: CTP synthase, 5-OXO-L-NORLEUCINE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: ctp synthase, pyrg, amidotransferase, utp, amp-pcp, 5-oxo-l-norleucine, ligase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129745.43

構造登録者

Bellinzoni, M.,Barilone, N.,Alzari, P.M. (登録日: 2015-04-17, 公開日: 2015-07-01, 最終更新日: 2024-01-10)

• 主引用文献: Mori, G.,Chiarelli, L.R.,Esposito, M.,Makarov, V.,Bellinzoni, M.,Hartkoorn, R.C.,Degiacomi, G.,Boldrin, F.,Ekins, S.,de Jesus Lopes Ribeiro, A.L.,Marino, L.B.,Centarova, I.,Svetlikova, Z.,Blasko, J.,Kazakova, E.,Lepioshkin, A.,Barilone, N.,Zanoni, G.,Porta, A.,Fondi, M.,Fani, R.,Baulard, A.R.,Mikusova, K.,Alzari, P.M.,Manganelli, R.,de Carvalho, L.P.,Riccardi, G.,Cole, S.T.,Pasca, M.R.; Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.; Chem.Biol., 22:917-927, 2015; PubMed: 26097035; DOI: 10.1016/j.chembiol.2015.05.016

実験手法

X-RAY DIFFRACTION (3.49 Å)