4ZC9

Crystal Structure of the BRD4a/DB-2-190 complex

4ZC9 の概要

• エントリーDOI: 10.2210/pdb4zc9/pdb
• 分子名称: Bromodomain-containing protein 4, 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}butyl)acetamide (3 entities in total)
• 機能のキーワード: bromodomain, small-molecule complex, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15884.65

構造登録者

Seo, H.-S.,DeAngelo, S.,Bradner, J.E. (登録日: 2015-04-15, 公開日: 2015-11-18, 最終更新日: 2024-03-06)

• 主引用文献: Winter, G.E.,Buckley, D.L.,Paulk, J.,Roberts, J.M.,Souza, A.,Dhe-Paganon, S.,Bradner, J.E.; DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.; Science, 348:1376-1381, 2015; PubMed: 25999370; DOI: 10.1126/science.aab1433

実験手法

X-RAY DIFFRACTION (0.99 Å)