4ZAU

AZD9291 complex with wild type EGFR

Summary for 4ZAU

• Entry DOI: 10.2210/pdb4zau/pdb
• Related: 4WRG
• Descriptor: Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide (3 entities in total)
• Functional Keywords: transferase, kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 38063.06

Authors

Squire, C.J.,Yosaatmadja, Y.,Flanagan, J.U.,McKeage, M. (deposition date: 2015-04-14, release date: 2015-11-11, Last modification date: 2023-09-27)

• Primary citation: Yosaatmadja, Y.,Silva, S.,Dickson, J.M.,Patterson, A.V.,Smaill, J.B.,Flanagan, J.U.,McKeage, M.J.,Squire, C.J.; Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed.; J.Struct.Biol., 192:539-544, 2015; PubMed: 26522274; DOI: 10.1016/j.jsb.2015.10.018

Experimental method

X-RAY DIFFRACTION (2.8 Å)