4Z9G

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry

4Z9G の概要

• エントリーDOI: 10.2210/pdb4z9g/pdb
• 関連するPDBエントリー: 4K5Y
• 分子名称: Corticotropin-releasing factor receptor 1,Lysozyme,Corticotropin-releasing factor receptor 1, OLEIC ACID, 3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine, ... (4 entities in total)
• 機能のキーワード: 7tm, gpcr, family b, signaling protein, g-protein, membrane, membrane protein, receptor, tncs, hexagonal
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P34998
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 156023.79

構造登録者

Dore, A.S.,Bortolato, A.,Hollenstein, K.,Cheng, R.K.Y.,Read, R.J.,Marshall, F.H. (登録日: 2015-04-10, 公開日: 2016-06-29, 最終更新日: 2024-01-10)

• 主引用文献: Dore, A.S.,Bortolato, A.,Hollenstein, K.,Cheng, R.K.Y.,Read, R.J.,Marshall, F.H.; Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures.; Curr Mol Pharmacol, 10:334-344, 2017; PubMed: 28183242; DOI: 10.2174/1874467210666170110114727

実験手法

X-RAY DIFFRACTION (3.183 Å)