4Z8C

Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin

This is a non-PDB format compatible entry.

Summary for 4Z8C

• Entry DOI: 10.2210/pdb4z8c/pdb
• Descriptor: 23S ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (59 entities in total)
• Functional Keywords: oncocin, antimicrobial peptide, antibiotic, 70s ribosome, inhibition of translation, peptidyl transferase inhibitors, 50s ribosomal subunit, peptide exit tunnel, ribosome-inhibitor complex, onc112, ribosome-antibiotic complex, ribosome/antibiotic
• Biological source: Escherichia coli; More
• Total number of polymer chains: 110
• Total formula weight: 4464601.48

Authors

Roy, R.N.,Lomakin, I.B.,Gagnon, M.G.,Steitz, T.A. (deposition date: 2015-04-08, release date: 2015-05-20, Last modification date: 2024-03-06)

• Primary citation: Roy, R.N.,Lomakin, I.B.,Gagnon, M.G.,Steitz, T.A.; The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin.; Nat.Struct.Mol.Biol., 22:466-469, 2015; PubMed: 25984972; DOI: 10.1038/nsmb.3031

Experimental method

X-RAY DIFFRACTION (2.9 Å)