4Z84

PKAB3 in complex with pyrrolidine inhibitor 34a

4Z84 の概要

• エントリーDOI: 10.2210/pdb4z84/pdb
• 関連するPDBエントリー: 1Q61 4Z83
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, ... (5 entities in total)
• 機能のキーワード: inhibitor, protein kinase, structure-guided, transferase
• 由来する生物種: Bos taurus (Bovine); 詳細
• 細胞内の位置: Cytoplasm : P00517
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43472.94

構造登録者

Lund, B.A.,Alam, K.A.,Engh, R.A. (登録日: 2015-04-08, 公開日: 2015-12-02, 最終更新日: 2024-01-10)

• 主引用文献: Lauber, B.S.,Hardegger, L.A.,Asraful, A.K.,Lund, B.A.,Dumele, O.,Harder, M.,Kuhn, B.,Engh, R.A.,Diederich, F.; Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.; Chemistry, 22:211-221, 2016; PubMed: 26578105; DOI: 10.1002/chem.201503552

実験手法

X-RAY DIFFRACTION (1.554 Å)