4Z73

Crystal structure of inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with a phosphate ion and an inorganic pyrophosphate

Summary for 4Z73

Entry DOI	10.2210/pdb4z73/pdb
Related	4Z70 4Z71 4Z72 4Z73
Descriptor	Inorganic pyrophosphatase, MANGANESE (II) ION, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	inorganic pyrophosphatase, tuberculosis, drug target, hydrolase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Cellular location	Cytoplasm : P9WI55
Total number of polymer chains	12
Total formula weight	236324.35
Authors	Pratt, A.C.,Biswas, T.,Tsodikov, O.V. (deposition date: 2015-04-06, release date: 2015-08-26, Last modification date: 2024-03-06)
Primary citation	Pratt, A.C.,Dewage, S.W.,Pang, A.H.,Biswas, T.,Barnard-Britson, S.,Cisneros, G.A.,Tsodikov, O.V. Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis. J.Struct.Biol., 192:76-87, 2015 Cited by PubMed: 26296329 DOI: 10.1016/j.jsb.2015.08.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation