4Z5R
Rontalizumab Fab bound to Interferon-a2
Summary for 4Z5R
Entry DOI | 10.2210/pdb4z5r/pdb |
Descriptor | Interferon alpha-2, anti-IFN-a antibody rontalizumab light chain, anti-IFN-a antibody rontalizumab heavy chain modules VH and CH1 (Fab), ... (4 entities in total) |
Functional Keywords | antibody, interferon, cytokine-immune system complex, cytokine/immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P01563 |
Total number of polymer chains | 24 |
Total formula weight | 540246.16 |
Authors | Eigenbrot, C.,Maurer, B.,Bosanac, I. (deposition date: 2015-04-02, release date: 2015-07-08, Last modification date: 2023-09-27) |
Primary citation | Maurer, B.,Bosanac, I.,Shia, S.,Kwong, M.,Corpuz, R.,Vandlen, R.,Schmidt, K.,Eigenbrot, C. Structural basis of the broadly neutralizing anti-interferon-alpha antibody rontalizumab. Protein Sci., 24:1440-1450, 2015 Cited by PubMed: 26099203DOI: 10.1002/pro.2729 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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