4Z41

X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Compound with a S,O Bidentate Ligand (9a=Chloro-(1-(3'-hydroxy)-3-(methylthio)-3-thioxo-prop-1-en-1-olate-O,S)-(dimethylsulfoxide-S)-platinum(II))

4Z41 の概要

• エントリーDOI: 10.2210/pdb4z41/pdb
• 分子名称: Lysozyme C, 3-[2-chloranyl-2-[dimethyl(oxidanyl)-{4}-sulfanyl]-4-ethylsulfanyl-1-oxa-3{3}-thia-2{4}-platinacyclohexa-3,5-dien-6-yl]phenol, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: pt compounds, anticancer agents, lysozyme complexes, hydrolase
• 由来する生物種: Gallus gallus (Chicken)
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15640.67

構造登録者

Merlino, A. (登録日: 2015-04-01, 公開日: 2015-09-02, 最終更新日: 2024-01-10)

• 主引用文献: Mugge, C.,Marzo, T.,Massai, L.,Hildebrandt, J.,Ferraro, G.,Rivera-Fuentes, P.,Metzler-Nolte, N.,Merlino, A.,Messori, L.,Weigand, W.; Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding.; Inorg.Chem., 54:8560-8570, 2015; PubMed: 26280387; DOI: 10.1021/acs.inorgchem.5b01238

実験手法

X-RAY DIFFRACTION (1.89 Å)