4Z36

Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-3080573

4Z36 の概要

• エントリーDOI: 10.2210/pdb4z36/pdb
• 関連するPDBエントリー: 4Z34 4Z35
• 分子名称: Lysophosphatidic acid receptor 1,Soluble cytochrome b562, 1-(4-{[(2S,3R)-2-(2,3-dihydro-1H-inden-2-yloxy)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]oxy}phenyl)cyclopropanecarboxylic acid, (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, ... (4 entities in total)
• 機能のキーワード: human lysophosphatidic acid receptor 1 (lpa1), g-protein coupled receptor (gpcr), membrane protein, antagonist, endogenous ligand, psi-biology, structural genomics, gpcr network, lipidic cubic phase (lcp), novel disulfide bond engineering, compound design, polypharmacology, lipid receptor, transport protein-inhibitor complex, transport protein/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell surface : Q92633
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52661.36

構造登録者

Chrencik, J.E.,Roth, C.B.,Terakado, M.,Kurata, H.,Omi, R.,Kihara, Y.,Warshaviak, D.,Nakade, S.,Asmar-Rovira, G.,Mileni, M.,Mizuno, H.,Griffith, M.T.,Rodgers, C.,Han, G.W.,Velasquez, J.,Chun, J.,Stevens, R.C.,Hanson, M.A.,GPCR Network (GPCR) (登録日: 2015-03-30, 公開日: 2015-06-03, 最終更新日: 2015-07-01)

• 主引用文献: Chrencik, J.E.,Roth, C.B.,Terakado, M.,Kurata, H.,Omi, R.,Kihara, Y.,Warshaviak, D.,Nakade, S.,Asmar-Rovira, G.,Mileni, M.,Mizuno, H.,Griffith, M.T.,Rodgers, C.,Han, G.W.,Velasquez, J.,Chun, J.,Stevens, R.C.,Hanson, M.A.; Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.; Cell, 161:1633-1643, 2015; PubMed: 26091040; DOI: 10.1016/j.cell.2015.06.002

実験手法

X-RAY DIFFRACTION (2.9 Å)