4Z22
structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor DR718A
Summary for 4Z22
| Entry DOI | 10.2210/pdb4z22/pdb |
| Descriptor | Plasmepsin-2, 2-amino-7-phenyl-3-{[(2R,5S)-5-phenyltetrahydrofuran-2-yl]methyl}quinazolin-4(3H)-one (3 entities in total) |
| Functional Keywords | plasmepsin ii, malaria, inhibitor, hydrolase |
| Biological source | Plasmodium falciparum |
| Total number of polymer chains | 2 |
| Total formula weight | 74614.17 |
| Authors | Recacha, R.,Leitans, J.,Tars, K.,Jaudzems, K. (deposition date: 2015-03-28, release date: 2016-01-13, Last modification date: 2024-01-10) |
| Primary citation | Rasina, D.,Otikovs, M.,Leitans, J.,Recacha, R.,Borysov, O.V.,Kanepe-Lapsa, I.,Domraceva, I.,Pantelejevs, T.,Tars, K.,Blackman, M.J.,Jaudzems, K.,Jirgensons, A. Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV. J.Med.Chem., 59:374-387, 2016 Cited by PubMed: 26670264DOI: 10.1021/acs.jmedchem.5b01558 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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