4Z1L

Yeast 20S proteasome in complex with belactosin C derivative 3

Summary for 4Z1L

• Entry DOI: 10.2210/pdb4z1l/pdb
• Related: 1RYP 3E47
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: hydrolase, proteasome, inhibitor, binding analysis, lead structure motif, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 733423.33

Authors

Huber, E.M.,Groll, M. (deposition date: 2015-03-27, release date: 2015-05-27, Last modification date: 2024-01-10)

• Primary citation: Groll, M.,Korotkov, V.S.,Huber, E.M.,de Meijere, A.,Ludwig, A.; A Minimal beta-Lactone Fragment for Selective beta 5c or beta 5i Proteasome Inhibitors.; Angew.Chem.Int.Ed.Engl., 54:7810-7814, 2015; PubMed: 25973989; DOI: 10.1002/anie.201502931

Experimental method

X-RAY DIFFRACTION (3 Å)