4Z0X

Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM

Summary for 4Z0X

Entry DOI	10.2210/pdb4z0x/pdb
Descriptor	Antibody HC26AM light chain variable domain, Antibody HC26AM heavy chain variable domain, HCV E2 Antigen (residues 432-446), ... (4 entities in total)
Functional Keywords	hcv, broadly neutralizing antibody, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	25641.42
Authors	Rangarajan, S.,Shahid, S.,Mariuzza, R.A. (deposition date: 2015-03-26, release date: 2016-07-20, Last modification date: 2023-10-25)
Primary citation	Keck, Z.Y.,Wang, Y.,Lau, P.,Lund, G.,Rangarajan, S.,Fauvelle, C.,Liao, G.C.,Holtsberg, F.W.,Warfield, K.L.,Aman, M.J.,Pierce, B.G.,Fuerst, T.R.,Bailey, J.R.,Baumert, T.F.,Mariuzza, R.A.,Kneteman, N.M.,Foung, S.K. Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice. Hepatology, 64:1922-1933, 2016 Cited by PubMed: 27641232 DOI: 10.1002/hep.28850 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation