4Z0X

Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM

4Z0X の概要

• エントリーDOI: 10.2210/pdb4z0x/pdb
• 分子名称: Antibody HC26AM light chain variable domain, Antibody HC26AM heavy chain variable domain, HCV E2 Antigen (residues 432-446), ... (4 entities in total)
• 機能のキーワード: hcv, broadly neutralizing antibody, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 25641.42

構造登録者

Rangarajan, S.,Shahid, S.,Mariuzza, R.A. (登録日: 2015-03-26, 公開日: 2016-07-20, 最終更新日: 2023-10-25)

• 主引用文献: Keck, Z.Y.,Wang, Y.,Lau, P.,Lund, G.,Rangarajan, S.,Fauvelle, C.,Liao, G.C.,Holtsberg, F.W.,Warfield, K.L.,Aman, M.J.,Pierce, B.G.,Fuerst, T.R.,Bailey, J.R.,Baumert, T.F.,Mariuzza, R.A.,Kneteman, N.M.,Foung, S.K.; Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.; Hepatology, 64:1922-1933, 2016; PubMed: 27641232; DOI: 10.1002/hep.28850

実験手法

X-RAY DIFFRACTION (2 Å)